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. 2017 May 18;17(1):341.
doi: 10.1186/s12885-017-3337-y.

Validation of the German version of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire

Katrin Hebestreit  1 , Maryam Yahiaoui-Doktor  2 , Christoph Engel  2 , Walter Vetter  3 , Michael Siniatchkin  4 , Nicole Erickson  5 , Martin Halle  6   7 , Marion Kiechle  8 , Stephan C Bischoff  1
Affiliations

Validation of the German version of the Mediterranean Diet Adherence Screener (MEDAS) questionnaire

Katrin Hebestreit et al. BMC Cancer. .

Abstract

Background: Health benefits of the Mediterranean Diet (MD) have been shown in different at-risk populations. A German translation of the Mediterranean Diet Adherence Screener (MEDAS) from the PREvención con DIeta MEDiterránea (PREDIMED) consortium was used in the LIBRE study, investigating effects of lifestyle-intervention on women with BRCA1/2 mutations. The purpose of the present study is to validate the MEDAS German version.

Methods: LIBRE is a multicentre (three university hospitals during this pilot phase), unblinded, randomized, controlled clinical trial. Women with a BRCA1/2 mutation of age 18 or over who provided written consent were eligible for the trial. As part of the assessment, all were given a full-length Food Frequency Questionnaire (FFQ) and MEDAS at baseline and after 3 months. Data derived from FFQ was compared to MEDAS in order to evaluate agreement or concordance between the two questionnaires. Additionally, the association of dietary intake biomarkers in the blood (β-carotene, omega-3, omega-6 and omega-9 fatty acids and high-sensitivity C-reactive protein (hsCRP)) with some MEDAS items was analyzed using t-Tests and a multivariate regression.

Results: The participants of the LIBRE pilot study were 68 in total (33 Intervention, 35 Control). Only participants who completed both questionnaires were included in this analysis (baseline: 66, month three: 54). The concordance between these two questionnaires varied between the items (Intraclass correlation coefficient of 0.91 for pulses at the highest and -0.33 for sugar-sweetened drinks). Mean MEDAS scores (sum of all items) were 9% higher than their FFQ counter-parts at baseline and 15% after 3 months. Higher fish consumption (at least 3 portions) was associated with lower omega-6 fatty acid levels (p = 0.026) and higher omega-3 fatty acid levels (p = 0.037), both results being statistically significant.

Conclusions: We conclude that the German MEDAS in its current version could be a useful tool in clinical trials and in practice to assess adherence to MD.

Trial registration: ClinicalTrials.gov , registered on March 12, 2014, identifier: NCT02087592 . World Health Organization Trial Registration, registered on 3 August 2015, identifier: NCT02087592 .

Keywords: BRCA1/2; Food frequency; Hereditary breast cancer; Mediterranean diet adherence; Validation.

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Figures

Fig. 1
Fig. 1
Bland-Altman plots showing the differences between the MEDAS score aggregated from MEDAS and FFQ questionnaires at baseline and after 3 months. The red dashed and dotted lines indicate the mean bias and its 95% confidence interval. The blue dashed and dotted lines depict limits of agreement and their 95% confidence intervals
Fig. 2
Fig. 2
Association of vegetable consumption (question 3 of the MEDAS questionnaire) and fruit consumption (question 4 of the MEDAS questionnaire) with β-carotene; and association of fish consumption (question 10 of the MEDAS questionnaire) with omega-6 fatty acids and omega-3 fatty acids after 3 months (V1) [0 = 0 point in the MEDAS question; 1 = 1 point in the MEDAS question]. The p-value was calculated using the t-test
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