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. 2017 May 18;15(1):19.
doi: 10.1186/s12963-017-0135-3.

Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study

Enrico Grande  1 , Antonella Zucchetto  2 , Barbara Suligoi  3 , Francesco Grippo  1 , Marilena Pappagallo  1 , Saverio Virdone  2 , Laura Camoni  3 , Martina Taborelli  2 , Vincenza Regine  3 , Diego Serraino  4 , Luisa Frova  1
Affiliations

Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study

Enrico Grande et al. Popul Health Metr. .

Abstract

Background: Multiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this study aimed to fully describe the cause-specific mortality of people with AIDS (PWA) compared to people without AIDS.

Methods: We conducted a nationwide investigation based on death certificates of 2,515 Italian PWA and 123,224 people without AIDS who had died between 2006 and 2010. The conditions most frequently associated with PWA mortality, compared to people without AIDS, were identified using an age-standardized proportion ratio (ASPR) calculated as the ratio between the age-standardized proportion of a specific cause among PWA and the same proportion among people without AIDS.

Results: The most frequently reported conditions at death among PWA were infectious/parasitic diseases (52%), digestive (36%), respiratory (33%), and circulatory (32%) system diseases, and neoplasms (29%). All AIDS-defining conditions resulted highly associated (ASPR significantly greater than unity) with PWA deaths. Significant associations also emerged for leishmaniasis (ASPR = 188.0), encephalitis/myelitis/encephalomyelitis (ASPR = 14.3), dementia (ASPR = 13.1), chronic viral hepatitis (ASPR = 13.1), liver fibrosis/cirrhosis (ASPR = 4.4), pneumonia (ASPR = 4.4), anal (ASPR = 12.1) and liver (ASPR = 1.9) cancers, and Hodgkin's disease (ASPR = 3.1).

Conclusions: Study findings identified the contribution of several non-AIDS-defining conditions on PWA mortality, emphasizing the need of preventive public health interventions targeting this population.

Keywords: Cause-specific mortality; HIV/AIDS; Italy; Multiple causes of death.

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Figures

Fig. 1
Fig. 1
Underlying cause (a) and multiple cause (b)of death distribution: a comparison between AIDS deaths and non-AIDS/HIV deaths. Italy, period 2006–2010. a ICD-10 codes B20-B24. In the representation of multiple causes for AIDS deaths, all the 2,515 certificates matched to the RAIDS are assumed to mention a B20-B24 code
See this image and copyright information in PMC

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