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Comment
. 2017 Jun;42(6):412-413.
doi: 10.1016/j.tibs.2017.04.008. Epub 2017 May 15.

Inhibiting Translation One Protein at a Time

Matthew D Disney  1
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Comment

Inhibiting Translation One Protein at a Time

Matthew D Disney. Trends Biochem Sci. 2017 Jun.

Abstract

Historically, translational inhibitors have been confined to anti-bacterials that globally affect translation. Lintner et al. demonstrate that small molecules can specifically inhibit translation of a single disease-associated protein by stalling the ribosome's nascent chain [1], opening up a new therapeutic strategy for 'undruggable' proteins.

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