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Review
. 2017 May 4:8:717.
doi: 10.3389/fmicb.2017.00717. eCollection 2017.

Animal Models for Tuberculosis in Translational and Precision Medicine

Lingjun Zhan  1   2   3   4   5 , Jun Tang  1   2   3   4   5 , Mengmeng Sun  1   2   3   4   5 , Chuan Qin  1   2   3   4   5
Affiliations
Review

Animal Models for Tuberculosis in Translational and Precision Medicine

Lingjun Zhan et al. Front Microbiol. .

Abstract

Tuberculosis (TB) is a health threat to the global population. Anti-TB drugs and vaccines are key approaches for TB prevention and control. TB animal models are basic tools for developing biomarkers of diagnosis, drugs for therapy, vaccines for prevention and researching pathogenic mechanisms for identification of targets; thus, they serve as the cornerstone of comparative medicine, translational medicine, and precision medicine. In this review, we discuss the current use of TB animal models and their problems, as well as offering perspectives on the future of these models.

Keywords: animal models; comparative medicine; precision medicine; translational medicine; tuberculosis.

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Figures

Figure 1
Figure 1
Current problems in diagnosis, treatment, and prevention of TB and the role of TB animal models.
Figure 2
Figure 2
The establish and application of monkey TB model.
See this image and copyright information in PMC

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