Does sleep disturbance affect the amyloid clearance mechanisms in Alzheimer's disease?

Abstract

Sleep is an important factor that plays a key role in Alzheimer's disease pathogenesis. However, it is still unclear whether poor-quality sleep may overlap with sleep disturbances in the underlying dysfunctional mechanisms of amyloid beta (Aβ) clearance metabolism. Here, we aimed to evaluate the current evidence on the role of sleep deprivation in Aβ clearance metabolism. To that end, we discuss possible mechanisms underlying the bidirectional interaction between the sleep deprivation and Aβ clearance pathways.

Keywords: Alzheimer's disease; amyloid beta clearance; glymphatic system; sleep; sleep deprivation.