RIPped for neuroinflammation
- PMID: 28524164
- PMCID: PMC5587852
- DOI: 10.1038/cr.2017.75
RIPped for neuroinflammation
Erratum in
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RIPped for neuroinflammation.Cell Res. 2017 Aug;27(8):1074. doi: 10.1038/cr.2017.97. Cell Res. 2017. PMID: 28761169 Free PMC article. No abstract available.
Abstract
Activation of the receptor interacting serine/threonine kinase (RIPK) 3 mediates an inflammatory type of cell death called necroptosis; in addition, RIPK3 has necroptosis-independent roles in inflammation, although these are not well defined. In a recent study published in Cell, Daniels and colleagues demonstrate that RIPK3 controls West Nile virus infection by promoting neuroinflammation in the central nervous system without affecting neuronal death.
Comment on
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RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.Cell. 2017 Apr 6;169(2):301-313.e11. doi: 10.1016/j.cell.2017.03.011. Epub 2017 Mar 30. Cell. 2017. PMID: 28366204 Free PMC article.
References
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- Weinlich R, Oberst A, Beere HM, et al. Nat Rev Mol Cell Biol 2017; 18:127–136. - PubMed
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