Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Jul;24(7):1140-1141.
doi: 10.1038/cdd.2017.75. Epub 2017 May 19.

Two paths to let the replisome go

Vincenzo D'Angiolella  1 , Daniele Guardavaccaro  2
Affiliations
Comment

Two paths to let the replisome go

Vincenzo D'Angiolella et al. Cell Death Differ. 2017 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Replisome unloading is controlled by two pathways. (a) During DNA replication termination, the CRL2LRR1 ubiquitin ligase and the p97 segregase trigger replisome unloading from chromatin. (b) An additional backup mechanism that depends on the p97 adaptor UBXN3 drives replisome unloading from mitotic chromatin. See text for details. For the sake of clarity, the different components of the replisome are not shown
See this image and copyright information in PMC

Comment on

References

    1. Diffley JF. Philos Trans R Soc Lond B Biol Sci 2011; 366: 3545–3553. - PMC - PubMed
    1. Truong LN et al. J Mol Cell Biol 2011; 3: 13–22. - PMC - PubMed
    1. Petroski MD et al. Nat Rev Mol Cell Biol 2005; 6: 9–20. - PubMed
    1. Maric M et al. Science 2014; 346: 1253596. - PMC - PubMed
    1. Moreno SP et al. Science 2014; 346: 477–481. - PubMed

Publication types

LinkOut - more resources