An Analysis of New Approaches and Drug Formulations for Treatment of Chronic Low Back Pain

Abstract

The prevalence of chronic low back pain (CLBP) is increasing. Treatment is effective in less than 50% of patients after 1 year. This review investigates new treatments for CLBP. An extensive literature review focuses on new treatments for CLBP. Their safety and efficacy were evaluated and are described in detail in this review. The investigation identified new treatments for CLBP including chemonucleolysis, platelet-rich plasma injections, artemin, tanezumab, and stem cells. Further research and innovation are needed to implement these methods into practice and assess clinical significance. The current evidence suggests that there are promising new agents for the treatment of CLBP.

Keywords: Artemin; Chemonucleolysis; Chronic low back pain; Collagenase; Ethanol; Matrix metalloproteinases; Platelet-rich plasma injections; Stem cells; Tanezumab.