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Review
. 2017 Nov;130(Pt B):223-232.
doi: 10.1016/j.pbiomolbio.2017.05.005. Epub 2017 May 16.

Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias

Niels Decher  1 , Aytug K Kiper  2 , Susanne Rinné  2
Affiliations
Review

Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias

Niels Decher et al. Prog Biophys Mol Biol. 2017 Nov.

Abstract

This review focuses on the role and the molecular candidates of the cardiac stretch-activated potassium current (SAK). The functional properties of the two-pore domain potassium (K2P) channel TREK-1, a major candidate for the cardiac SAK, are analyzed and the molecular mechanism of stretch-activation in K2P potassium channels is discussed. Furthermore, the functional modulation of TREK-1 by different cardiac interaction partners, as well as evidence for the functional role of the stretch-dependent TREK-1 and its putative subunits in the heart is reviewed. In addition, we summarize the recent evidence that TREK-1 is involved in the pathogenesis of human cardiac arrhythmias.

Keywords: K(2P) channel; MEF; SAC; SAK; Stretch-activated ion channel; TREK-1.

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