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Randomized Controlled Trial
. 2017 Aug:180:1-7.
doi: 10.1016/j.ajo.2017.05.008. Epub 2017 May 17.

Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study

David Weakley  1 , George Cotsonis  2 , M Edward Wilson  3 , David A Plager  4 , Edward G Buckley  5 , Scott R Lambert  6 ; Infant Aphakia Treatment Study Group
Affiliations
Randomized Controlled Trial

Anisometropia at Age 5 Years After Unilateral Intraocular Lens Implantation During Infancy in the Infant Aphakia Treatment Study

David Weakley et al. Am J Ophthalmol. 2017 Aug.

Abstract

Purpose: To report the prevalence of anisometropia at age 5 years after unilateral intraocular lens (IOL) implantation in infants.

Design: Prospective randomized clinical trial.

Methods: Fifty-seven infants in the Infant Aphakia Treatment Study (IATS) with a unilateral cataract were randomized to IOL implantation with an initial targeted postoperative refractive error of either +8 diopters (D) (infants 28 to <48 days of age) or +6 D (infants 48-210 days of age). Anisometropia was calculated at age 5 years. Six patients were excluded from the analyses.

Results: Median age at cataract surgery was 2.2 months (interquartile range [IQR], 1.2, 3.5 months). The mean age at the age 5 years follow-up visit was 5.0 ± 0.1 years (range, 4.9-5.4 years). The median refractive error at the age 5 years visit of the treated eyes was -2.25 D (IQR -5.13, +0.88 D) and of the fellow eyes +1.50 D (IQR +0.88, +2.25). Median anisometropia was -3.50 D (IQR -8.25, -0.88 D); range -19.63 to +2.75 D. Patients with glaucoma in the treated eye (n = 9) had greater anisometropia (glaucoma, median -8.25 D; IQR -11.38, -5.25 D vs no glaucoma median -2.75; IQR -6.38, -0.75 D; P = .005).

Conclusions: The majority of pseudophakic eyes had significant anisometropia at age 5 years. Anisometropia was greater in patients that developed glaucoma. Variability in eye growth and myopic shift continue to make refractive outcomes challenging for IOL implantation during infancy.

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Figures

Figure 1
Figure 1
Bar graph showing spread of refractive errors in the pseudophakic eye at age 5 years.
Figure 2
Figure 2
Bar graph showing spread of refractive errors in the fellow eye at age 5 years.
Figure 3
Figure 3
Bar graph showing spread of anisometropia between the treated and fellow eyes at age 5 years.
Figure 4
Figure 4
Plot of the refractive error at the first postoperative refraction in the treated eye versus anisometropia at age 5 years.
Figure 5
Figure 5
Plot of power of the intraocular lens implanted in the treated eye versus anisometropia at age 5 years.
See this image and copyright information in PMC

References

    1. Gordon RA, Donzis PB. Refractive development of the human eye. Arch Ophthalmol. 1985;103(6):785–789. - PubMed
    1. Manzitti E, Gamio S, Damel A, Benozzi J. Eye length in congenital cataracts. In: Cotlier E, Lambert S, Taylor D, editors. Congenital Cataracts. Austin, Texas: R.G. Landes Company; 1994. pp. 251–259.
    1. Bradley DV, Fernandes A, Lynn M, Tigges M, Boothe RG. Emmetropization in the rhesus monkey (Macaca mulatta): birth to young adulthood. Invest Ophthalmol Vis Sci. 1999;40(1):214–229. - PubMed
    1. Allen RJ, Speedwell L, Russell-Eggitt I. Long-term visual outcome after extraction of unilateral congenital cataracts. Eye (Lond) 2010;24(7):1263–1267. - PubMed
    1. Chen YC, Hu AC, Rosenbaum A, Spooner S, Weissman BA. Long-term results of early contact lens use in pediatric unilateral aphakia. Eye Contact Lens. 2010;36(1):19–25. - PubMed

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