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Comment
. 2017 Jun 5;214(6):1564-1566.
doi: 10.1084/jem.20170842. Epub 2017 May 19.

Tissue-resident T cells in hepatitis B: A new target for cure?

Fabian J Bolte  1 , Barbara Rehermann  1
Affiliations
Comment

Tissue-resident T cells in hepatitis B: A new target for cure?

Fabian J Bolte et al. J Exp Med. .

Abstract

A hallmark of chronic hepatitis B virus (HBV) infection is the functional impairment and depletion of antiviral T cells. In this issue of JEM, Pallett et al. (https://doi.org/10.1084/jem.20162115) identify a reservoir of functional HBV-specific T cells among liver-resident T cells.

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Figures

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Insight from Fabian J. Bolte and Barbara Rehermann
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(A) TRM cells are enriched in the HBV-infected liver, and their frequency correlates inversely with HBV titer. (B) CD8+ TRM cells reside in the liver sinusoids. They express the tissue-homing marker CD69, and a subset additionally expresses the integrin CD103. TRM cells display a unique transcriptional profile (T-betlo, Eomeslo, Notchhi). Despite high expression levels of the inhibitory receptor PD-1, they readily produce antiviral cytokines upon in vitro stimulation.
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References

    1. Boni C., et al. J. Virol. 2007 doi: 10.1128/JVI.02844-06. - DOI - PubMed
    1. Fisicaro P., et al. Gastroenterology. 2010 doi: 10.1053/j.gastro.2009.09.052. - DOI - PubMed
    1. Guidotti L.G., et al. Science. 1999 doi: 10.1126/science.284.5415.825. - DOI - PubMed
    1. Ishizuka A.S., et al. Nat. Med. 2016 doi: 10.1038/nm.4110. - DOI - PubMed
    1. Isogawa M., et al. Immunity. 2005 doi: 10.1016/j.immuni.2005.05.005. - DOI - PubMed

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