Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul;14(7):578-580.
doi: 10.1038/cmi.2017.28. Epub 2017 May 22.

A vestigial pathway for sex differences in immune regulation

Affiliations

A vestigial pathway for sex differences in immune regulation

Yun Liang et al. Cell Mol Immunol. 2017 Jul.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
VGLL3-regulated gene network promotes autoimmunity. The female-biased expression and nuclear localization of VGLL3 leads to elevated expression of pro-autoimmune genes, which may help explain the increased susceptibility of females to autoimmune diseases.

References

    1. Clayton JA, Collins FS. Policy: NIH to balance sex in cell and animal studies. Nature 2014; 509: 282–283. - PMC - PubMed
    1. Whitacre CC. Sex differences in autoimmune disease. Nat Immunol 2001; 2: 777–780. - PubMed
    1. Klein SL, Flanagan KL. Sex differences in immune responses. Nat Rev Immunol 2016; 16: 626–638. - PubMed
    1. Geary DC. Sex differences in social behavior and cognition: utility of sexual selection for hypothesis generation. Horm Behav 2006; 49: 273–275. - PubMed
    1. Folstad I, Karter AJ. Parasites, bright males, and the immunocompetence handicap. Am Nat 1992; 139: 603–622.

Publication types

Substances