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. 2017 May 8;15(2):1559325817704760.
doi: 10.1177/1559325817704760. eCollection 2017 Apr-Jun.

Radiotherapy for Pertussis: An Historical Assessment

Edward J Calabrese  1 , Gaurav Dhawan  2 , Rachna Kapoor  3
Affiliations

Radiotherapy for Pertussis: An Historical Assessment

Edward J Calabrese et al. Dose Response. .

Abstract

X-ray therapy was used to treat pertussis/whooping cough during a 13-year period from 1923 to 1936 in North America and Europe. Twenty studies from clinicians in the United States reported that approximately 1500 cases of pertussis were treated by X-ray therapy usually with less than 0.5 erythema dose. Young children (<3 years) comprised about 70% to 80% of the cases, with the age of cases ranging from as young as 1 month to 50 years. In general, symptoms of severe coughing, vomiting episodes, and spasms were significantly relieved in about 85% of cases following up to 3 treatments, while about 15% of the cases showed nearly full relief after only 1 treatment. The X-ray therapy was also associated with a marked reduction in mortality of young (<3 years) children by over 90%. Despite such reported clinical success from a wide range of experienced researchers, the use of X-rays for the treatment of pertussis in young children was controversial, principally due to concerns of exposure to the thymus and thyroid even with the availability of lead shielding. By the mid-1930s, the treatment of pertussis cases via vaccine therapy came to dominate the therapeutic arena, and the brief era of a radiotherapy option for the treatment of pertussis ended.

Keywords: X-rays; history of science; hormesis; pertussis; radiotherapy; whooping cough.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

    1. Henry JE. A brief statistical study of recent experience with measles and whooping cough in Massachusetts. Am J Public Health (N Y). 1921;11(4):302–306. - PMC - PubMed
    1. Geier D, Geier M. The true story of pertussis vaccination: a sordid legacy? J Hist Med Allied Sci. 2002;57(3):249–284. - PubMed
    1. Bowditch HI, Smith L. Roentgen ray treatment of whooping cough. Trans Am Climatol Clin Assoc. 1925;41:53–64. - PMC - PubMed
    1. Bowditch HI, Leonard RD. Preliminary report on the treatment of pertussis by the X-ray. Bos Med Surg J. 1923;188(10):312–313.
    1. Smith LW, Bowditch HI, Leonard RD, et al. Treatment of pertussis by the roentgen ray. An analysis of eight hundred and fifty cases. JAMA. 1925;85(3):171–177.

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