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Comment
. 2017 Jun;66(6):1467-1469.
doi: 10.2337/dbi17-0018.

Checks and Balances-The Limits of β-Cell Endurance to ER Stress

Decio L Eizirik  1 , Alexandra Coomans de Brachène  2
Affiliations
Comment

Checks and Balances-The Limits of β-Cell Endurance to ER Stress

Decio L Eizirik et al. Diabetes. 2017 Jun.
No abstract available

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Figures

Figure 1
Figure 1
The research strategy of Pappalardo et al. (2) leading to the identification of Spry2 and its function. Based on a whole-genome RNAi screen in insulin-producing MIN6 cells, 26 novel regulators of insulin transcription were identified, including both transcription factors that directly bind to the insulin promoter and mRNAs that regulate basic β-cell functions that interfere with insulin production. Functional studies focused on Spry2, a candidate gene for type 2 diabetes, and in vitro studies indicated that this gene is induced by ER stress, downstream of the PERK pathway, and regulates expression of the Ca2+ pump Serca2. These findings were partially validated in an in vivo mouse model of β-cell–specific knockout of Spry2. GWAS, genome-wide association study; Ins, insulin; TFs, transcription factors.
See this image and copyright information in PMC

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References

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