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Multicenter Study
. 2017 Jun;31(3):217-229.
doi: 10.3341/kjo.2016.0018. Epub 2017 May 12.

Predictors and Outcomes of Vitrectomy and Silicone Oil Injection in Advanced Diabetic Retinopathy

Alireza Ramezani  1   2   3 , Hamid Ahmadieh  2   4 , Amin Rozegar  2 , Masoud Soheilian  2   4 , Morteza Entezari  2   4 , Siamak Moradian  1   4 , Mohammad H Dehghan  2   4 , Homayoun Nikkhah  2 , Mehdi Yaseri  2   5
Affiliations
Multicenter Study

Predictors and Outcomes of Vitrectomy and Silicone Oil Injection in Advanced Diabetic Retinopathy

Alireza Ramezani et al. Korean J Ophthalmol. 2017 Jun.

Abstract

Purpose: To evaluate visual and anatomical results and identify factors that influence vitrectomy and silicone oil (SO) injection outcomes in proliferative diabetic retinopathy (PDR).

Methods: This retrospective study included 236 eyes with PDR that were undergoing vitrectomy and SO injection with >3-month follow-up. The primary outcomes were final best-corrected visual acuity (BCVA) and retinal attachment rate.

Results: At the final visit (mean, 88 ± 58 weeks), complete, partial, and no retinal attachment were observed in 86.9%, 10.6%, and 2.5% of patients, respectively. A total of 155 eyes had experienced SO removal, while 81 had SO in place. The mean initial BCVA was 1.9 ± 0.7 logarithm of the minimum angle of resolution (logMAR) and significantly improved to 1.7 ± 0.8 logMAR (p = 0.001). Initial macular detachment (adjusted odds ratio [AOR], 0.25), development of iatrogenic break (AOR, 0.25), and use of heavy SO (AOR, 0.13) were independently associated with a lower risk of final retinal attachment, and SO removal was associated with a higher incidence (AOR, 7.55). Better baseline BCVA was associated with a higher risk of final BCVA ≥20 / 200.

Conclusions: Despite an encouraging outcome based on anatomical data in advanced PDR treated with vitrectomy and SO, the functional prognosis was not satisfying for patients. Eyes with better vision at baseline had a more favorable prognosis, whereas eyes with initial macular detachment, intraoperative iatrogenic break, or heavy SO showed more unfavorable outcomes. In selected cases, extending the time of SO use did not worsen the prognosis.

Keywords: Diabetic retinopathy; Outcome; Silicone oils; Vitrectomy.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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