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Case Reports
. 2017 Sep:53:89-93.
doi: 10.1016/j.meegid.2017.05.017. Epub 2017 May 20.

Analysis of Anelloviridae sequences characterized from serial human and animal biological samples

Sandra Bédarida  1 , Bertrand Dussol  2 , Michel Signoli  3 , Philippe Biagini  4
Affiliations
Case Reports

Analysis of Anelloviridae sequences characterized from serial human and animal biological samples

Sandra Bédarida et al. Infect Genet Evol. 2017 Sep.

Abstract

Rolling-circle amplification-sequence-independent single primer amplifications (RCA-SISPA) and/or RCA-PCR-based approaches were applied to serial human plasma and animal (domestic cat) saliva samples. Complete SENV-H-related and PRA4 Anelloviridae genomes were characterized and analysed over time (~16 and 6.5years for human and animal samples, respectively). Genomic sequences and deduced putative coding regions were compared. Comparable values, i.e. ~2×10-4subs/site/year, were obtained for estimated rates of non-synonymous substitutions. A "hot-spot" of mutations located on the SENV-H-related ORF1 was identified. These results are first data concerning Anelloviridae evolution in a human and an animal host based on the analysis of complete sequences.

Keywords: Anelloviridae; Animal; Evolution; Genome; Human; Virus.

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