New connections: How to become more flexible and open up

Wei Wong¹

Affiliations

Comment

Wei Wong. Sci Signal. 2017.

. 2017 May 23;10(480):eaan7911.

doi: 10.1126/scisignal.aan7911.

Wei Wong¹

Abstract

Cryo-EM-generated structures provide insight into how RyR2 is gated and how phosphorylation may affect the activation process.

Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2.
Peng W, Shen H, Wu J, Guo W, Pan X, Wang R, Chen SR, Yan N. Peng W, et al. Science. 2016 Oct 21;354(6310):aah5324. doi: 10.1126/science.aah5324. Epub 2016 Sep 22. Science. 2016. PMID: 27708056
A cryo-EM-based model of phosphorylation- and FKBP12.6-mediated allosterism of the cardiac ryanodine receptor.
Dhindwal S, Lobo J, Cabra V, Santiago DJ, Nayak AR, Dryden K, Samsó M. Dhindwal S, et al. Sci Signal. 2017 May 23;10(480):eaai8842. doi: 10.1126/scisignal.aai8842. Sci Signal. 2017. PMID: 28536302