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Review
. 2017 Mar-Apr;51(2):274-287.
doi: 10.7868/S0026898417020148.

[CAR T-cell therapy: Balance of efficacy and safety]

[Article in Russian]
S V Kulemzin  1 , V V Kuznetsova  1 , M Mamonkin  2 , A V Taranin  1   3 , A A Gorchakov  1   3   4
Affiliations
Free article
Review

[CAR T-cell therapy: Balance of efficacy and safety]

[Article in Russian]
S V Kulemzin et al. Mol Biol (Mosk). 2017 Mar-Apr.
Free article

Abstract

Early results from clinical trials of autologous chimeric antigen receptor (CAR)-expressing T cells for the therapy of B-cell malignancies have encouraged extending the potency of this therapy to other cancers. However, the success of using CAR T-cells to treat patients with solid tumors has been limited. In this review, we summarize current knowledge on the design and applications of CARs for the targeted therapy of cancer. We describe existing issues that limit the widespread application of CAR T cells and discuss the optimization steps needed to further improve safety and efficacy of this therapeutic platform.

Keywords: T-cells; adoptive immunotherapy; cancer; chimeric antigen receptor.

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