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Editorial
. 2017 Jun 20;8(25):39941-39942.
doi: 10.18632/oncotarget.17990.

APOE genotype and Alzheimer's immunotherapy

Joanna E Pankiewicz  1 , Martin J Sadowski  1
Affiliations
Editorial

APOE genotype and Alzheimer's immunotherapy

Joanna E Pankiewicz et al. Oncotarget. .
No abstract available

Keywords: Alzheimer’s disease; amyloid related imaging abnormalities; apolipoprotein E; b-amyloid; microglia.

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Figures

Figure 1
Figure 1. Interaction between APOE genotype, Aβ deposition, and microglia
The APOE ε4 allele is associated with greater β-amyloid (Aβ) deposition than APOE ε2 and ε3 alleles. Aβ parenchymal plaques attract microglia cells and cause their peri-plaque activation, which is proportional to Aβ plaque load across all APOE genotypes. Therapeutic anti-Aβ monoclonal antibodies (mAbs) bind deposited Aβ and activate microglia cells to clear Aβ through Fc receptor-mediated phagocytosis. The APOE ε4 allele is associated with greater microglia activation than APOE alleles ε2 and ε3 resulting in greater clearance of Aβ plaque load during Aβ-directed passive immunization.
See this image and copyright information in PMC

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