Altered peripheral profile of blood cells in Alzheimer disease: A hospital-based case-control study

Abstract

Alzheimer disease (AD) has been made a global priority for its multifactorial pathogenesis and lack of disease-modifying therapies. We sought to investigate the changes of profile of blood routine in AD and its correlation with the disease severity.In all, 92 AD patients and 84 age and sex-matched normal controls were enrolled and their profiles of blood routine were evaluated.Alzheimer disease patients had increased levels of mean corpuscular hemoglobin, mean corpuscular volume, red cell distribution width-standard deviation, mean platelet volume,and decreased levels of platelet distribution width, red blood cell, hematocrit, hemoglobin, lymphocyte, and basophil compared with normal controls.Alterations in quantity and quality of blood cells may be involved in the pathogenesis of AD and contribute to the disease progression.

Figure 1

Comparison of indices of blood cells between AD patients (n = 92) and NCs (normal control) (n = 84). HCT (A), HGB (B), LYM (C), MCH (D), MCHC (E), MCV (F), MONO (G), NEU (H), RBC (I), RDW-SD (J), WBC (K), PLT (L) levels in AD patients and NCs. HCT = hematocrit, HGB = hemoglobin, LYM = lymphocyte, MCH = mean corpuscular hemoglobin, MCHC = mean corpuscular hemoglobin concentration, MCV = mean corpuscular volume, MONO = monocyte, NEU = neutrophil, RBC = red blood cell, RDW-SD = red cell distribution width-standard deviation, WBC = white blood cell. Data are expressed as mean ± SE (standard error).

Figure 2

The levels of FOLW (A), VB12 (B), BASO (C),PDW (D), MPV (E), ESO (F), and ratio of MONO (G), LYM (H), NEU (I) to WBC in AD patients (n = 92) and NCs (normal controls) (n = 84). BASO = basophil, ESO = eosinophilia, FOLW = folic acid, LYM = lymphocyte, MONO = monocyte, MPV = mean platelet volume, NEU = neutrophil, PDW = platelet distribution width, VB12 =  vitamin B12, WBC = white blood cell. Data are expressed as mean ± SE (standard error).