doi: 10.1016/s0031-6989(88)80127-9.
Vascular reactivity to methoxamine in conscious sinoaortic denervated rats
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- PMID: 2853877
- DOI: 10.1016/s0031-6989(88)80127-9
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Vascular reactivity to methoxamine in conscious sinoaortic denervated rats
Pharmacol Res Commun.
1988 Nov.
Abstract
Alterations in vascular alpha-adrenoceptor responsiveness following sinoaortic denervation was studied in conscious rats. The arterial hypertension observed in baroreceptor denervated rats decreased progressively during the 30 days of observation. A pressor hyperresponsiveness to methoxamine (10-80 micrograms/kg, iv), was observed 3 to 7 days after baroreceptor denervation followed by a gradual normalization of the vascular reactivity. The results indicate a possible participation of an enhanced alpha 1-adrenoceptor-mediated vasoconstrictor component in the early phase of neurogenic hypertension.
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