Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov;20(11):993-9.
doi: 10.1016/s0031-6989(88)80127-9.

Vascular reactivity to methoxamine in conscious sinoaortic denervated rats

M R Moysés  1 , A M Cabral, E C Vasquez
Affiliations

Vascular reactivity to methoxamine in conscious sinoaortic denervated rats

M R Moysés et al. Pharmacol Res Commun. 1988 Nov.

Abstract

Alterations in vascular alpha-adrenoceptor responsiveness following sinoaortic denervation was studied in conscious rats. The arterial hypertension observed in baroreceptor denervated rats decreased progressively during the 30 days of observation. A pressor hyperresponsiveness to methoxamine (10-80 micrograms/kg, iv), was observed 3 to 7 days after baroreceptor denervation followed by a gradual normalization of the vascular reactivity. The results indicate a possible participation of an enhanced alpha 1-adrenoceptor-mediated vasoconstrictor component in the early phase of neurogenic hypertension.

PubMed Disclaimer

Publication types