Longevity Klotho gene polymorphism and the risk of dementia in older men

Osvaldo P Almeida¹, Bharti Morar², Graeme J Hankey³, Bu B Yeap⁴, Jonathan Golledge⁵, Assen Jablensky⁶, Leon Flicker⁷

Affiliations

¹ School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia; WA Centre for Health & Ageing of Centre for Medical Research, Harry Perkins Institute of Medical Research, Perth, Australia; Department of Psychiatry, Royal Perth and Bentley Hospitals, Perth, Australia. Electronic address: osvaldo.almeida@uwa.edu.au.
² Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, MRF Building, 50 Murray Street, Perth 6000, Australia; Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia; Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA 6009, Australia.
³ School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia.
⁴ School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Endocrinology, Fiona Stanley Hospital, Perth, Australia.
⁵ Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Australia; Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia.
⁶ School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia; Department of Psychiatry, Royal Perth and Bentley Hospitals, Perth, Australia; Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, MRF Building, 50 Murray Street, Perth 6000, Australia.
⁷ WA Centre for Health & Ageing of Centre for Medical Research, Harry Perkins Institute of Medical Research, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Geriatric Medicine, Royal Perth Hospital, Perth, Australia.

PMID: 28539162
DOI: 10.1016/j.maturitas.2017.04.005

Longevity Klotho gene polymorphism and the risk of dementia in older men

Osvaldo P Almeida et al. Maturitas. 2017 Jul.

. 2017 Jul:101:1-5.

doi: 10.1016/j.maturitas.2017.04.005. Epub 2017 Apr 8.

Authors

Osvaldo P Almeida¹, Bharti Morar², Graeme J Hankey³, Bu B Yeap⁴, Jonathan Golledge⁵, Assen Jablensky⁶, Leon Flicker⁷

Affiliations

¹ School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia; WA Centre for Health & Ageing of Centre for Medical Research, Harry Perkins Institute of Medical Research, Perth, Australia; Department of Psychiatry, Royal Perth and Bentley Hospitals, Perth, Australia. Electronic address: osvaldo.almeida@uwa.edu.au.
² Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, MRF Building, 50 Murray Street, Perth 6000, Australia; Cooperative Research Centre for Mental Health, Carlton South, Victoria, Australia; Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, 6 Verdun Street, Nedlands, WA 6009, Australia.
³ School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia.
⁴ School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Endocrinology, Fiona Stanley Hospital, Perth, Australia.
⁵ Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, Australia; Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, Australia.
⁶ School of Psychiatry & Clinical Neurosciences, University of Western Australia, Perth, Australia; Department of Psychiatry, Royal Perth and Bentley Hospitals, Perth, Australia; Centre for Clinical Research in Neuropsychiatry, School of Psychiatry and Clinical Neurosciences, University of Western Australia, MRF Building, 50 Murray Street, Perth 6000, Australia.
⁷ WA Centre for Health & Ageing of Centre for Medical Research, Harry Perkins Institute of Medical Research, Perth, Australia; School of Medicine and Pharmacology, University of Western Australia, Perth, Australia; Department of Geriatric Medicine, Royal Perth Hospital, Perth, Australia.

PMID: 28539162
DOI: 10.1016/j.maturitas.2017.04.005

Abstract

Introduction: Klotho variants (KL-VS) have been associated with increased longevity and better cognitive function. It is unclear whether they modulate dementia risk.

Methods: We recruited 527 men aged 71-87 years who were free of cognitive impairment. We used data linkage to track the onset of dementia over 10 years. KL-VS genotyping (rs9536314 T/G) followed standard procedures.

Results: The annual rate of dementia was 17.2‰ (95%CI=14.0-21.1; total=5053 person-years), and 14.0‰ (95%CI=10.6-18.4; 3582 person-years), 23.5‰ (95%CI=16.6-33.2; 1363 person-years) and 46.4‰ (95%CI=19.3-111.5; 108 person-years) for men with the TT, TG and GG genotypes. Compared with the TT genotype, the sub-hazard ratios of dementia associated with the TG and GG genotypes were 1.6 (95%CI=1.0, 2.5; p=0.030) and 3.5 (95%CI=1.3, 9.1; p=0.011).

Discussion: The Klotho KL-VS variant is associated with an increase in the incidence of dementia in older men, in a dose-dependent fashion (intermediate for heterozygosis and highest for homozygosis).

Keywords: Alzheimer; Cognitive impairment; Cohort study; Dementia; Epidemiology; Klotho; Risk factor.

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Longevity Klotho gene polymorphism and the risk of dementia in older men

Affiliations

Longevity Klotho gene polymorphism and the risk of dementia in older men

Authors

Affiliations

Abstract

MeSH terms

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LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Miscellaneous