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Comparative Study
. 1988;10(6):66-8.

[Effect of ascorbic acid on the hepatocarcinogenic action of N-nitrosodiethylamine in rats]

[Article in Russian]
R V Birk, L A Kil'dema, L E Teras
  • PMID: 2854047
Comparative Study

[Effect of ascorbic acid on the hepatocarcinogenic action of N-nitrosodiethylamine in rats]

[Article in Russian]
R V Birk et al. Eksp Onkol. 1988.

Abstract

It is shown that the ascorbic acid (AA) administration to Wistar male rats (50 mg per animal intraperitoneally 3 times a week) accelerates hepatocarcinogenesis induced by N-nitrosodiethylamine (2.5 mg/kg 6 times a week in drinking water). In this case the activity of glucose-6-phosphate dehydrogenase in liver increases, while that of glucose-6-phosphatase decreases.

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