Review
doi: 10.1093/rheumatology/kex186.
The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade
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- PMID: 28541488
- DOI: 10.1093/rheumatology/kex186
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Review
The role of IL-12/23 in T cell-related chronic inflammation: implications of immunodeficiency and therapeutic blockade
Rheumatology (Oxford).
.
Abstract
In this review we discuss the divergent role of two closely related cytokines, IL-12 and IL-23, in shaping immune responses. In light of current therapeutic developments using biologic agents to block these two pathways, a better understanding of the immunological function of these cytokines is pivotal.
Keywords: IL-12 related immunodeficiency; IL-12/23 blockade; briakinumab; psoriasis; psoriatic arthritis; ustekinumab.
© The Author 2017. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
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