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. 2017 May 18;12(5):e0177931.
doi: 10.1371/journal.pone.0177931. eCollection 2017.

Clinical impact of chronic obstructive pulmonary disease on non-cystic fibrosis bronchiectasis. A study on 1,790 patients from the Spanish Bronchiectasis Historical Registry

David De la Rosa  1 , Miguel-Angel Martínez-Garcia  2 , Rosa Maria Giron  3 , Montserrat Vendrell  4 , Casilda Olveira  5 , Luis Borderias  6 , Luis Maiz  7 , Antoni Torres  8 , Eva Martinez-Moragon  9 , Olga Rajas  3 , Francisco Casas  10 , Rosa Cordovilla  11 , Javier de Gracia  12
Affiliations

Clinical impact of chronic obstructive pulmonary disease on non-cystic fibrosis bronchiectasis. A study on 1,790 patients from the Spanish Bronchiectasis Historical Registry

David De la Rosa et al. PLoS One. .

Abstract

Background: Few studies have evaluated the coexistence of bronchiectasis (BE) and chronic obstructive pulmonary disease (COPD) in series of patients diagnosed primarily with BE. The aim of this study was to analyse the characteristics of patients with BE associated with COPD included in the Spanish Bronchiectasis Historical Registry and compare them to the remaining patients with non-cystic fibrosis BE.

Methods: We conducted a multicentre observational study of historical cohorts, analysing the characteristics of 1,790 patients who had been included in the registry between 2002 and 2011. Of these, 158 (8.8%) were registered as BE related to COPD and were compared to the remaining patients with BE of other aetiologies.

Results: Patients with COPD were mostly male, older, had a poorer respiratory function and more frequent exacerbations. There were no differences in the proportion of patients with chronic bronchial colonisation or in the isolated microorganisms. A significantly larger proportion of patients with COPD received treatment with bronchodilators, inhaled steroids and intravenous antibiotics, but there was no difference in the use of long term oral or inhaled antibiotherapy. During a follow-up period of 3.36 years, the overall proportion of deaths was 13.8%. When compared to the remaining aetiologies, patients with BE associated with COPD presented the highest mortality rate. The multivariate analysis showed that the diagnosis of COPD in a patient with BE as a primary diagnosis increased the risk of death by 1.77.

Conclusion: Patients with BE related to COPD have the same microbiological characteristics as patients with BE due to other aetiologies. They receive treatment with long term oral and inhaled antibiotics aimed at controlling chronic bronchial colonisation, even though the current COPD treatment guidelines do not envisage this type of therapy. These patients' mortality is notably higher than that of remaining patients with non-cystic fibrosis BE.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Study flowchart.
BE: bronchiectasis; CF: cystic fibrosis; COPD: chronic obstructive pulmonary disease.
Fig 2
Fig 2. Severity of patients with bronchiectasis secondary to COPD according to GOLD staging.
COPD: chronic obstructive pulmonary disease.
Fig 3
Fig 3. Presence of chronic bronchial colonisation.
(A) Chronic bronchial colonisation by any microorganism according to functional severity group. (B) Chronic bronchial colonisation by P. aeruginosa according to functional severity group. BE: bronchiectasis: COPD: chronic obstructive pulmonary disease.
Fig 4
Fig 4. Presence of exacerbations during the previous year.
(A) According to CBC by any microorganism. (B) According to CBC by P. aeruginosa. BE: bronchiectasis; CBC: chronic bronchial colonisation; COPD: chronic obstructive pulmonary disease; PA: Pseudomonas aeruginosa.
Fig 5
Fig 5. Kaplan Meier survival curve: Cumulative percentage of survivors per non-cystic fibrosis bronchiectasis aetiology.
Curves compared by means of the log-rank test: COPD curve vs. other aetiologies curves (log-rank 38.800; p<0.0001).
See this image and copyright information in PMC

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