Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2017 May 25;12(5):e0177247.
doi: 10.1371/journal.pone.0177247. eCollection 2017.

Structural parameters associated with location of peaks of peripapillary retinal nerve fiber layer thickness in young healthy eyes

Takehiro Yamashita  1 , Ryo Asaoka  2 , Yuya Kii  1 , Hiroto Terasaki  1 , Hiroshi Murata  2 , Taiji Sakamoto  1
Affiliations
Observational Study

Structural parameters associated with location of peaks of peripapillary retinal nerve fiber layer thickness in young healthy eyes

Takehiro Yamashita et al. PLoS One. .

Abstract

The location of the peaks of the circumpapillary retinal nerve fiber layer (cpRNFL) thickness is affected by several ocular parameters. In this study, we have generated equations that can determine the peaks of the cpRNFL. This study was a prospective, observational, cross sectional study of 118 healthy right eyes. The axial length, optic disc tilt, superiortemporal (ST)- and inferiortemporal (IT)-peaks of the cpRNFL thickness, and angles of the ST and IT retinal arteries (RA) and veins (RV) were determined. The correlations between the location of the ST- and IT-peaks and ocular structural parameters and the sex, body height and weight were calculated. The best fit equations to generate the location of the ST/IT-peaks were determined using corrected-Akaike Information Criteria. The location of the ST-peak was 0.72+(0.40 x ST-RA)+(0.27 x ST-RV)+(0.14 x height)-(0.47 x papillo-macular-position)-(0.11 x disc tilt) with a coefficient of correlation of 0.61 (P<0.0001). The location of the IT-peak was 21.88+(0.53 x IT-RA)+(0.15 x IT-RV)+(0.041 x corneal thickness)-(1.00 x axial length) with a coefficient of correlation of 0.59 (P<0.0001). The location of ST/IT peaks is determined by different parameters of the ocular structure. These equations allow clinicians to obtain an accurate location of the peaks for a more accurate diagnosis of glaucoma.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Schematic drawings of ocular and systemic parameters related to the examined ST-peak and IT-peak.
ST: supratemporal, IT: infratemporal.
Fig 2
Fig 2. Histogram of supratemporal and infratemporal peak circumpapirally retinal nerve fiber layer thickness angle (ST- and IT-peak).
ST: supratemporal, IT: infratemporal.
Fig 3
Fig 3. Factors affect supratemporal RNFL peak thickness position.
See this image and copyright information in PMC

References

    1. Quigley HA, Katz J, Derick RJ, Gilbert D, Sommer A. An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage. Ophthalmology 1992;99:19–28 - PubMed
    1. Sommer A, Katz J, Quigley HA, Miller NR, Robin AL, Richter RC, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss. Arch Ophthalmol 1991;109:77–83 - PubMed
    1. Blumenthal EZ, Williams JM, Weinreb RN, Girkin CA, Berry CC,Linda M, Zangwill LM. Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography. Ophthalmology. 2000;107:2278–82. - PubMed
    1. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, et al. Optical coherence tomography. Science. 1991;254:1178–81. - PMC - PubMed
    1. Mistlberger A, Liebmann JM, Greenfield DS, Pons ME, Hoh ST, Ishikawa H, et al. Heidelberg retina tomography and optical coherence tomography in normal, ocular-hypertensive, and glaucomatous eyes. Ophthalmology. 1999;106:2027–32. 10.1016/S0161-6420(99)90419-0 - DOI - PubMed

Publication types

LinkOut - more resources