Electric properties tomography: Biochemical, physical and technical background, evaluation and clinical applications

Abstract

Electric properties tomography (EPT) derives the patient's electric properties, i.e. conductivity and permittivity, using standard magnetic resonance (MR) systems and standard MR sequences. Thus, EPT does not apply externally mounted electrodes, currents or radiofrequency (RF) probes, as is the case in competing techniques. EPT is quantitative MR, i.e. it yields absolute values of conductivity and permittivity. This review summarizes the physical equations underlying EPT, the corresponding basic and advanced reconstruction techniques and practical numerical aspects to realize these reconstruction techniques. MR sequences which map the field information required for EPT are outlined, and experiments to validate EPT in phantom and in vivo studies are described. Furthermore, the review describes the clinical findings which have been obtained with EPT so far, and attempts to understand the physiologic background of these findings.

Keywords: EPT; electric conductivity; numerical differentiation; permittivity; tumor characterization.