Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2017 Dec;64(12).
doi: 10.1002/pbc.26642. Epub 2017 May 24.

Severe cytokine release syndrome in a patient receiving PD-1-directed therapy

Seth J Rotz  1 , Daniel Leino  2 , Sara Szabo  2 , Jennifer L Mangino  1 , Brian K Turpin  1 , Joseph G Pressey  1
Affiliations
Case Reports

Severe cytokine release syndrome in a patient receiving PD-1-directed therapy

Seth J Rotz et al. Pediatr Blood Cancer. 2017 Dec.

Abstract

Cytokine release syndrome (CRS) is a phenomenon of immune hyperactivation described in the setting of cellular and bispecific T-cell engaging immunotherapy. Checkpoint blockade using anti-programmed cell death 1 (anti-PD-1) inhibitors is an approach to antitumor immune system stimulation. A 29-year-old female with alveolar soft part sarcoma developed severe CRS after treatment with anti-PD-1 therapy. CRS was characterized by high fevers, encephalopathy, hypotension, hypoxia, hepatic dysfunction, and evidence of coagulopathy, and resolved after infusion of the interleukin-6 inhibitor tocilizumab and corticosteroids.

Keywords: IL-6; PD-1 inhibitor; cytokine release syndrome; nivolumab; tocilizumab.

PubMed Disclaimer

Publication types