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. 2017 May 17;12(5):e0177593.
doi: 10.1371/journal.pone.0177593. eCollection 2017.

Polyphenols and IUGR pregnancies: Maternal hydroxytyrosol supplementation improves prenatal and early-postnatal growth and metabolism of the offspring

Marta Vazquez-Gomez  1 , Consolación Garcia-Contreras  2 , Laura Torres-Rovira  2 , José Luis Pesantez  2 , Pedro Gonzalez-Añover  1 , Ernesto Gomez-Fidalgo  2 , Raúl Sanchez-Sanchez  2 , Cristina Ovilo  2 , Beatriz Isabel  1 , Susana Astiz  2 , Antonio Gonzalez-Bulnes  2
Affiliations

Polyphenols and IUGR pregnancies: Maternal hydroxytyrosol supplementation improves prenatal and early-postnatal growth and metabolism of the offspring

Marta Vazquez-Gomez et al. PLoS One. .

Abstract

Hydroxytyrosol is a polyphenol with antioxidant, metabolism-regulatory, anti-inflammatory and immuno-modulatory properties. The present study aimed to determine whether supplementing the maternal diet with hydroxytyrosol during pregnancy can improve pre- and early post-natal developmental patterns and metabolic traits of the offspring. Experiment was performed in Iberian sows fed a restricted diet in order to increase the risk of IUGR. Ten sows were treated daily with 1.5 mg of hydroxytyrosol per kg of feed between Day 35 of pregnancy (30% of total gestational period) until delivery whilst 10 animals were left untreated as controls. Number and weight of offspring were assessed at birth, on post-natal Day 15 and at weaning (25 days-old). At weaning, body composition and plasma indexes of glucose and lipids were measured. Treatment with hydroxytyrosol was associated with higher mean birth weight, lower incidence of piglets with low birth weight. Afterwards, during the lactation period, piglets in the treated group showed a higher body-weight than control piglets; such effects were even stronger in the most prolific litters. These results suggest that maternal supplementation with hydroxytyrosol may improve pre- and early post-natal development of offspring in pregnancies at risk of IUGR.

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Conflict of interest statement

Competing Interests: There is no conflict of interest that would prejudice the information offered in the paper, excepting that AGB and CO are PLOS ONE Editorial Board members. However, this does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Figures

Fig 1
Fig 1. Changes in body-weight (Kg/day) of piglets throughout the lactation period.
The panel A represents total differences between groups of treatment. Panels B, C and D represent between-treatments differences considering litter size (2–6, 7–8 and 9–10 piglets, respectively). Panels E and F represent within-treatment differences considering litter size in control and treated groups, respectively. Dark blue: Hydroxytyrosol group. Green: Control group. Red: 9–10 piglets/litter. Light blue: 8–7 piglets/litter. Black: 2–6 piglets/litter.
Fig 2
Fig 2. Changes in ADWG (Kg/day ± S.E.M.) of piglets throughout lactation period.
The panel A represents total differences between groups of treatment. Panels B, C and D represent between-treatments differences considering litter size (2–6, 7–8 and 9–10 piglets, respectively). Panels E and F represent within-treatment differences considering litter size in control and treated groups, respectively. Dark blue: Hydroxytyrosol group. Green: Control group. Red: 9–10 piglets/litter. Light blue: 8–7 piglets/litter. Black: 2–6 piglets/litter.
See this image and copyright information in PMC

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