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. 2017 Aug;31(8):1272-1274.
doi: 10.1016/j.jdiacomp.2017.04.018. Epub 2017 Apr 19.

Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

Andreea Ciudin  1 , Ana Espinosa  2 , Olga Simó-Servat  1 , Agustín Ruiz  2 , Montserrat Alegret  2 , Cristina Hernández  1 , Mercè Boada  2 , Rafael Simó  3
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Type 2 diabetes is an independent risk factor for dementia conversion in patients with mild cognitive impairment

Andreea Ciudin et al. J Diabetes Complications. 2017 Aug.

Abstract

Aims: To explore whether type 2 diabetes (T2D) is a risk factor for dementia conversion in patients with mild cognitive impairment (MCI).

Methods: A longitudinal nested case-control study in which 101 T2D patients and 101 non-diabetic patients with MCI matched by age and gender were included.

Results: The dementia conversion rate was 57.4% in T2D patients vs. 42.6% in non-diabetic subjects (p=0.02). T2D and APOE ε4 allele were independent risk factors for developing dementia.

Conclusion: T2D is an independent risk factor for dementia conversion in MCI patients. This finding has significant clinical implications.

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