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. 2017 Sep;124(3):365-369.
doi: 10.1016/j.radonc.2017.05.003. Epub 2017 May 22.

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s

Pierre Montay-Gruel  1 , Kristoffer Petersson  2 , Maud Jaccard  2 , Gaël Boivin  3 , Jean-François Germond  2 , Benoit Petit  3 , Raphaël Doenlen  4 , Vincent Favaudon  5 , François Bochud  2 , Claude Bailat  2 , Jean Bourhis  3 , Marie-Catherine Vozenin  6
Affiliations

Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s

Pierre Montay-Gruel et al. Radiother Oncol. 2017 Sep.

Abstract

This study shows for the first time that normal brain tissue toxicities after WBI can be reduced with increased dose rate. Spatial memory is preserved after WBI with mean dose rates above 100Gy/s, whereas 10Gy WBI at a conventional radiotherapy dose rate (0.1Gy/s) totally impairs spatial memory.

Keywords: Cognition’s preservation; Flash-RT; Whole brain irradiation.

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