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Editorial
. 2017 May 26;120(11):1696-1698.
doi: 10.1161/CIRCRESAHA.117.311022.

GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family

Fan Fan  1 , Richard J Roman  2
Affiliations
Editorial

GPR75 Identified as the First 20-HETE Receptor: A Chemokine Receptor Adopted by a New Family

Fan Fan et al. Circ Res. .
No abstract available

Keywords: Editorials; blood pressure; blood vessels; cell proliferation; hypertension; inflammation.

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Figures

Figure 1
Figure 1
Hypothetical incorporation of the GPR75 signaling pathways in attempt to explain the established vascular and renal tubular effects of 20-HETE. The effects of 20-HETE to uncouple eNOS, promote endothelial dysfunction and increase the expression of ACE in the endothelium are presented in Panel A. Panel B presents the vasoconstrictor action of 20-HETE in VSMCs. The natriuretic effects of 20-HETE in the proximal tubule and thick ascending loop of Henle are summarized in Panels C and D. Arrows indicate increased activity, while crosses indicate inhibitory actions. Question marks indicate actions that are not fully defined.
See this image and copyright information in PMC

Comment on

References

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