Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 May 26;120(11):1721-1723.
doi: 10.1161/CIRCRESAHA.117.310672.

Redox Stress Defines the Small Artery Vasculopathy of Hypertension: How Do We Bridge the Bench-to-Bedside Gap?

Rhian M Touyz  1 , Augusto C Montezano  2 , Francisco Rios  2 , Michael E Widlansky  2 , Mingyu Liang  2
Affiliations
Review

Redox Stress Defines the Small Artery Vasculopathy of Hypertension: How Do We Bridge the Bench-to-Bedside Gap?

Rhian M Touyz et al. Circ Res. .

Abstract

While convincing experimental evidence demonstrates the importance of vascular reactive oxygen and nitrogen species (RONS), oxidative stress and perturbed redox signaling as causative processes in the vasculopathy of hypertension, this has not translated to the clinic. We discuss this bench-to-bedside disparity and the urgency to progress vascular redox pathobiology from experimental models to patients by studying disease-relevant human tissues. It is only through such approaches that the unambiguous role of vascular redox stress will be defined so that mechanism-based therapies in a personalized and precise manner can be developed to prevent, slow or reverse progression of small vessel disorders and consequent hypertension.

Keywords: blood pressure; cardiovascular diseases; hypertension; oxidative stress; stroke.

PubMed Disclaimer

References

    1. Olsen MH, Angell SY, Asma S, et al. A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension. Lancet. 2016;388:2665–2712. - PubMed
    1. Chobanian AV. Shattuck Lecture. The hypertension paradox--more uncontrolled disease despite improved therapy. N Engl J Med. 2009;361:878–887. - PubMed
    1. Ehret GB, Ferreira T, Chasman DI, et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet. 2016;48:1171–1184. - PMC - PubMed
    1. Fazakas Á, Szelényi Z, Szénási G, Nyírő G, Szabó PM, Patócs A, Tegze N, Fekete BC, Molvarec A, Nagy B, Jakus J, Örsi F, Karádi I, Vereckei A. Genetic predisposition in patients with hypertension and normal ejection fraction to oxidative stress. J Am Soc Hypertens. 2016;10:124–32. - PubMed
    1. Schiffrin EL. Mechanisms of remodeling of small arteries, antihypertensive therapy and the immune system in hypertension. Clin Invest Med. 2015;38:394–402. - PubMed

Publication types