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Review
. 2017 Jun;8(2):160-168.
doi: 10.1007/s13193-016-0584-3. Epub 2017 Jan 23.

Screening and Detection of Prostate Cancer-Review of Literature and Current Perspective

Ananthakrishnan Sivaraman  1 , Kulthe Ramesh Seetharam Bhat  1
Affiliations
Review

Screening and Detection of Prostate Cancer-Review of Literature and Current Perspective

Ananthakrishnan Sivaraman et al. Indian J Surg Oncol. 2017 Jun.

Abstract

Screening of prostatic cancer is a matter of debate among uro-oncologist. With many new screening modalities like prostatic health index (PHI), 4K testing the role of screening has increased as one is able to stratify patients with serum prostate specific antigen level in a grey zone of 4-10 ng/ml and normal digital rectal examination into various risk groups, thus avoiding unnecessary biopsy which was the pitfalls of routine screening practice. PHI is better at predicting malignancy while 4K is better at predicting high-grade disease. This in combination with multiparametric MRI especially with prostate imaging reporting and data system score has made screening less difficult and more meaningful for a practising uro-oncologist.

Keywords: Newer screening modalities; PIRADS; Prostate cancer; Screening.

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Figures

Fig. 1
Fig. 1
Receiver operating curves for prostatic health index [35]
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References

    1. Partin AW, Mangold LA, Lamm DM, Walsh PC, Epstein JI, Pearson JD (2001) Contemporary update of prostate cancer staging nomograms (Partin tables) for the new millennium. Urology 58(6):843–8. Available from: http://www.sciencedirect.com/science/article/pii/S0090429501014418 - PubMed
    1. Aslan G, Irer B, Cimen S, Goktay Y, Celebi I, Tuna B, et al. (2011) The performance of abnormal digital rectal examination for the detection of prostate cancer at stratified prostate specific antigen levels. Open J Urol 01(04):67–71. Scientific Research Publishing. Available from: http://www.scirp.org/journal/PaperInformation.aspx?PaperID=8221&#abstract
    1. Meeks JJ, Loeb S, Helfand BT, Kan D, Smith ND, Catalona WJ (2009) Characteristics of prostate cancers detected at prostate specific antigen levels less than 2.5 ng/ml. J Urol 181(6):2515–8; discussion 2518–9. Available from: http://www.sciencedirect.com/science/article/pii/S0022534709002729 - PMC - PubMed
    1. Catalona WJ, Smith DS, Ratliff TL, Dodds KM, Coplen DE, Yuan JJJ, et al. (1991) Measurement of prostate-specific antigen in serum as a screening test for prostate cancer N Engl J Med:1156–61. Available from: https://www.ncbi.nlm.nih.gov/pubmed/7506853 - PubMed
    1. Thompson IM, Pauler DK, Goodman PJ, Tangen CM, Lucia MS, Parnes HL, et al. (2004) Prevalence of prostate cancer among men with a prostate-specific antigen level < or =4.0 ng per milliliter. N Engl J Med 350(22):2239–46. Available from: http://www.ncbi.nlm.nih.gov/pubmed/15163773 - PubMed

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