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Case Reports
. 2017 Jun;8(2):203-205.
doi: 10.1007/s13193-016-0581-6. Epub 2016 Nov 18.

A Rare Presentation of Infantile Virilization Secondary to Malignant Etiology

V Dasarwar Nagesh  1 , D Ramkrishnan Santosh  1 , N Datla Sravya  1
Affiliations
Case Reports

A Rare Presentation of Infantile Virilization Secondary to Malignant Etiology

V Dasarwar Nagesh et al. Indian J Surg Oncol. 2017 Jun.

Abstract

Adrenocortical tumor is a rare malignancy (1-2/million) in children with a heterogenous presentation and generally poor prognosis. We report two cases of adrenocortical carcinoma who presented primarily with virilization along with cushingoid features and hypertension. Both children were managed with surgical resection of tumor, steroid replacement, and antihypertensives.

Keywords: Adrenocortical carcinoma; Clitoromegaly; Cushing syndrome; Virilization.

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Figures

Fig. 1
Fig. 1
a–c Cushingoid habitus, buffalo hump, truncal obesity, moon facies, and pubic hair growth
Fig. 2
Fig. 2
Clinical picture of child 3 months post resection of ACC, showing complete recovery
Fig. 3
Fig. 3
CT abdomen showing right adrenal cell carcinoma
Fig. 4
Fig. 4
MRI abdomen showing left adrenal cell carcinoma
See this image and copyright information in PMC

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References

    1. Tauchmanova L, Colao A, Marzano LA, Sparanol, Camera L, Rossa, Palmieri G, Rossi R. Adrenocortical carcinoma: twelve year prospective experience. World J Surg 2004, 28: 896–903 - PubMed
    1. Ng.L, Libertino JM: Adrenocortical carcinoma: diagnosis, evaluation and treatment. J Urol 2003, 169: 5–11 - PubMed
    1. Riberio RC, Michalkiewicz EL, Figueiredo BC, Delacerda L, Sandrini F, Pianorsky MD, et al. Adrenocortical tumors in children. Braz J Med Biol Res. 2000;33:1225–1234. doi: 10.1590/S0100-879X2000001000013. - DOI - PubMed
    1. Michalekiewicz E, Sandhni R, Figueiredo BC, Miranda EC, Caran E, Oliveira Filho AG, et al. Clinical and outcome characteristics of children with adrenocortical tumors: a report from the International Pediatric Adrenocortical Tumor Registry. J Clin Oncol. 2004;22:838–845. doi: 10.1200/JCO.2004.08.085. - DOI - PubMed
    1. Abiven G, Coste J, L Groussin, Anract P, Tissier F, Legmanoop, et al. Clinical and biological features in the prognosis of adrenocortical cancer, poor outcome of cortisol secreting tumors in a series of 202 consecutive patients. J.Clin. endocrinol.metab.2006.gl:2650–55 - PubMed

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