Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Dec;10(4):211-216.

Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Red Blood Cell Distribution Width-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency

Gulsah Ilhan  1 , Fatma Ferda Verit Atmaca  1 , Esra Altan  1 , Ali Galip Zebitay  1 , Hamdullah Sozen  1 , Hurkan Akyol  1 , Meryem Kurek Eken  2
Affiliations

Evaluation of Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio and Red Blood Cell Distribution Width-Platelet Ratio for Diagnosis of Premature Ovarian Insufficiency

Gulsah Ilhan et al. J Family Reprod Health. 2016 Dec.

Abstract

Objective: To evaluate whether systemic inflammatory markers (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and red blood cell distribution width (RDW) to platelet ratio (RPR)) can be used as reliable markers for the diagnosis of premature ovarian insufficiency (POI) and to determine if there is a relationship between these markers and follicle stimulating hormone (FSH), Anti-Müllerian Hormone (AMH) levels. Materials and methods: Written and electronic medical records were reviewed using searches for diagnoses with the terms of 'premature ovarian failure', 'premature ovarian insufficiency'. Patients younger than the age of 40 were diagnosed to have premature ovarian insufficiency based on their menstrual history and sonographic examination and they were compared with healthy females. Complete blood counts, day-3 hormone profiles, AMH levels of all subjects were analyzed. Results: NLR was statistically higher in POI group compared with controls (p < 0.05). NLR had a positive correlation between FSH (r = 0.23, p = 0.045) and a negative association with AMH (r = - 0.27, p = 0.018). The area under ROC curve for NLR in POI was 0.66, with a threshold value 1.5 and sensitivity = 75.7 % and specificity = 46.0 %. Conclusion: NLR can be a marker for the diagnosis of POI. There is a close relationship between NLR and ovarian reserve markers such as FSH and AMH.

Keywords: Inflammation Marker; Premature Ovarian Insufficiency.

PubMed Disclaimer

Figures

Figure 1
Figure 1
ROC Curve analysis for NLR
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Jewelwicz R, Schwartz M. Premature ovarian failure. Bull N Y Acad Med. 1986;62:219–36. - PMC - PubMed
    1. Laughlin D, ThorneyCroft IH. Amenorrhea. In: Decherne AH, Nathan LI, editors. Current Obstetric & Gynecologic Diagnosis & Treatment. 9th ed. . New York: McGraw-Hill; 2003. pp. 991–1000.
    1. Board JA, Redwine FO, Moncure CW, Frable WJ, Taylor JR. Identification of differing etiologies of clinically diagnosed premature menopause. Am J Obstet Gynecol. 1979;134:936–44. - PubMed
    1. Pal L, Santoro N. Premature ovarian failure(POF): discordance between somatic and reproductive aging. Ageing Res Rev. 2002;1:413–23. - PubMed
    1. Rees M, Purdie D. Premature menopause. In: Rees M, Purdie D, editors. Management of the menopause: the handbook. London: Royal Society of Medicine Press Ltd; 2006.

LinkOut - more resources