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. 2017 May 18;10(5):711-716.
doi: 10.18240/ijo.2017.05.08. eCollection 2017.

Comparison of corneal biomechanics in Sjögren's syndrome and non-Sjögren's syndrome dry eyes by Scheimpflug based device

Qin Long  1 , Jing-Yi Wang  1 , Dong Xu  2 , Ying Li  1
Affiliations

Comparison of corneal biomechanics in Sjögren's syndrome and non-Sjögren's syndrome dry eyes by Scheimpflug based device

Qin Long et al. Int J Ophthalmol. .

Abstract

Aim: To compare the corneal biomechanics of Sjögren's syndrome (SS) and non-SS dry eyes with Corneal Visualization Scheimpflug Technology (CorVis ST).

Methods: Corneal biomechanics and tear film parameters, namely the Schirmer I test value, tear film break-up time (TBUT) and corneal staining score (CSS) were detected in 34 eyes of 34 dry eye patients with SS (SSDE group) and 34 dry eye subjects without SS (NSSDE group) using CorVis ST. The differences of the above parameters between the two groups were examined, and the relationship between corneal biomechanics and tear film parameters were observed.

Results: The differences in age, sex, intraocular pressure (IOP) and central corneal thickness (CCT) were not significant between the two groups (P>0.05). The tear film parameters had significant differences between the SSDE group and NSSDE group (all P<0.05). Patients in the SSDE group had significantly lower A1-time and HC-time, but higher DA (P=0.01, 0.02, and 0.02, respectively) compared with the NSSDE group. In the SSDE group, DA was negatively correlated with TBUT (rho=-0.38, P=0.03); HC-time was negatively correlated with CSS (rho=-0.43, P=0.02). In the NSSDE group, HC-time was again negatively correlated with CSS (rho=-0.39, P=0.02).

Conclusion: There are differences in corneal biomechanical properties between SSDE and NSSDE. The cornea of SSDE tends to show less "stiffness", as seen by a significantly shorter A1-time and HC-time, but larger DA, compared with the cornea of NSSDE. Biomechanical parameters can be influenced by different tear film parameters in both groups.

Keywords: Sjögren's syndrome; corneal biomechanics; dry eye.

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Figures

Figure 1
Figure 1. Box and whisker plots show the distribution between the SSDE group and NSSDE group for DA (A), A1-time (B) and HC time (C).
The median for each data set is marked by the center line, with the error bars showing the minimum and maximum values of all of the data, n=34.
Figure 2
Figure 2. Scatter diagrams of bivariate correlation analysis
A: Correlation between the DA and TBUT in SSDE group; B: Correlation between the HC-time and CSS in SSDE group; C: Correlation between the HC-time and CSS in non-SSDE group. rho: Spearman's correlation coefficient value.
See this image and copyright information in PMC

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References

    1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007) Ocul Surf. 2007;5(2):75–92. - PubMed
    1. Elsheikh A, Alhasso D, Rama P. Assessment of the epithelium's contribution to corneal biomechanics. Exp Eye Res. 2008;86(2):445–451. - PubMed
    1. Akpek EK, Klimava A, Thorne JE, Martin D, Lekhanont K, Ostrovsky A. Evaluation of patients with dry eye for presence of underlying Sjogren syndrome. Cornea. 2009;28(5):493–497. - PMC - PubMed
    1. Luciano N, Valentini V, Calabrò A, Elefante E, Vitale A, Baldini C, Bartoloni E. One year in review 2015: Sjögren syndrome. Clin Exp Rheumatol. 2015;33(2):259–271. - PubMed
    1. Maślińska M, Przygodzka M, Kwiatkowska B, Sikorska-Siudek K. Sjögren's syndrome: still not fully understood disease. Rheumatol Int. 2015;35(2):233–241. - PMC - PubMed

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