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. 2017 Jul;134(1):159-162.
doi: 10.1007/s00401-017-1728-4. Epub 2017 May 25.

Low-grade spinal glioneuronal tumors with BRAF gene fusion and 1p deletion but without leptomeningeal dissemination

Jason C H Chiang  1 , Julie H Harreld  2 , Brent A Orr  1 , Suash Sharma  3 , Azzam Ismail  4 , Annette D Segura  5 , David W Ellison  6
Affiliations

Low-grade spinal glioneuronal tumors with BRAF gene fusion and 1p deletion but without leptomeningeal dissemination

Jason C H Chiang et al. Acta Neuropathol. 2017 Jul.
No abstract available

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Figures

Figure 1
Figure 1. Imaging Features of Spinal BRAF-fused and 1p-deleted Glioneuronal Tumors
Sagittal (a, b) and axial (c, d) fat-saturated T2 (a, c) and contrast-enhanced T1-weighted images (b, d) show multi-cystic tumor with peripheral and nodular enhancement, filling and expanding the central canal of the spinal cord across multiple spinal segments.
Figure 2
Figure 2. Histologic Features of Spinal BRAF-fused and 1p-deleted Glioneuronal Tumors
The oligodendrocyte-like cytology of the tumor is evident on both smear preparations (a) and fixed histologic sections (b). Axons are seen among oligodendrocyte-like cells (OLCs), giving away their infiltrative nature. Neuropil-like islands are often surrounded by tumor cells and have a rosette-like configuration (c). OLCs are immunopositive for OLIG2 (d) and immunonegative for GFAP (e). Synaptophysin immunoreactivity marks tumor cells and highlights neuropil islands (f).
See this image and copyright information in PMC

References

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