Itraconazole therapy for fungal keratitis

Abstract

110 cases of keratomycosis were treated with itraconazole administered either orally or topically or by both routes. Excellent or moderate response was obtained in 69 percent of the patients. Ulcers due to Aspergillus and dematiaceous fungi and non-sevee ulcers responded better than did severe ulcers and ulcers due to Fusarium. A combination of oral and topical itraconazole yielded the highest percentage of excellent or moderate responses.