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. 2017 Oct;140(4):1194-1196.e16.
doi: 10.1016/j.jaci.2017.04.039. Epub 2017 May 23.

Regulatory T-cell populations in children are affected by age and food allergy diagnosis

Benjamin T Prince  1 , Ashley L Devonshire  2 , Kristin A Erickson  3 , Jenna Bergerson  2 , Dalia Fuleihan  3 , Christine Szychlinski  2 , Robert P Schleimer  3 , Paul J Bryce  3 , Anne Marie Singh  4
Affiliations

Regulatory T-cell populations in children are affected by age and food allergy diagnosis

Benjamin T Prince et al. J Allergy Clin Immunol. 2017 Oct.
No abstract available

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Conflict of interest statement

Conflicts of Interest/Corporate Sponsors: None

Figures

Figure 1
Figure 1. Comparison of the percentage of CD25+CD127loFoxp3 Tcells in peripheral blood mononuclear cells from children with and without food allergy
A. Comparison of CD25+CD127loFoxp3+ CD4+ T cells populations between control and food allergic children. B. Mean fluorescence intensity (MFI) of Foxp3 in CD25+CD127loFoxp3+ cells between food allergic and control children. C. CD25+CD127loFoxp3+ T-cell percentage in young children (<6 years) and older children (7–17 years). D and E. Linear correlation of age and CD25+CD127loFoxp3+ percentage in control and food allergic children. **p=0.007 for control children. *p<0.05, **p<0.01, Mann-Whitney U test. Black bars represent the median. MFI: Mean Fluorescence Intensity.
Figure 2
Figure 2. Phenotypic Characterization of tTregs (CD25+CD127loFoxp3+CD4+ T cells
A The percentage of peripheral blood tTregs (CD25+CD127loFoxp3+T cells) expressing CCR6 in control and food allergic children. B. The percentage of peripheral blood tTregs (CD25+CD127loFoxp3+T cells) in control and food allergic children in young (≤ 6 years) and older (> 6 years) control and food allergic children that express the putative gut homing marker, CCR6. *p=0.01; #p<0.1. Black bars represent the median.
See this image and copyright information in PMC

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