Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Jul;33(7):1177-1184.
doi: 10.1007/s00381-017-3461-7. Epub 2017 May 26.

Fetoscopic patch coverage of experimental myelomenigocele using a two-port access in fetal sheep

Lucie Guilbaud  1   2 , Nathalie Roux  3 , Stéphanie Friszer  3   4 , Charles Garabedian  3 , Ferdinand Dhombres  3   4 , Bettina Bessières  5 , Catherine Fallet-Bianco  6 , Federico Di Rocco  7 , Michel Zerah  8   9 , Jean-Marie Jouannic  3   4
Affiliations

Fetoscopic patch coverage of experimental myelomenigocele using a two-port access in fetal sheep

Lucie Guilbaud et al. Childs Nerv Syst. 2017 Jul.

Abstract

Purpose: This study aims to assess the feasibility and the effectiveness of a fetoscopic myelomeningocele (MMC) coverage using a sealed inert patch through a two-port access, in the sheep model.

Methods: Forty-four fetuses underwent surgical creation of a MMC defect at day 75 and were divided into four groups according to the MMC repair technique, performed at day 90. Group 1 remained untreated. Group 2 had an open surgery using suture of the defect. Groups 3 and 4 underwent defect coverage using a Gore®-polytetrafluoroethylene patch secured with surgical adhesive (Bioglue®), with an open approach (group 3) and a fetoscopic one (group 4). Lambs were killed at term, and histological examinations were performed.

Results: Fetoscopic patch coverage was achieved in all the lambs of group 4. All the fetuses of group 2 had a complete closure of the defect whereas only 38% in group 3 and 14% in group 4. Fetal loss rate seems to be lower in group 4 than in groups 2 and 3.

Conclusion: Fetoscopic coverage of MMC defect can be performed using a sealed patch through a two-port access, but the patch and glue correction may not be the ideal technique to repair fetal MMC.

Keywords: Fetal surgery; Fetal therapy; Fetoscopy; Open spina bifida; Sheep.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. N Engl J Med. 2011 Mar 17;364(11):993-1004 - PubMed
    1. Am J Obstet Gynecol. 2000 Nov;183(5):1119-23 - PubMed
    1. Am J Obstet Gynecol. 2010 Jan;202(1):85.e1-9 - PubMed
    1. Fetal Diagn Ther. 2000 Mar-Apr;15(2):83-8 - PubMed
    1. Dev Med Child Neurol. 2012 Jan;54(1):15-22 - PubMed

LinkOut - more resources