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. 2017 Aug;10(4):501-510.
doi: 10.1016/j.tranon.2017.03.004. Epub 2017 May 24.

Laparoscopic Versus Open Radical Nephrectomy for Renal Cell Carcinoma: a Systematic Review and Meta-Analysis

Gang Liu  1 , Yulei Ma  1 , Shouhua Wang  2 , Xiancheng Han  1 , Dianjun Gao  1
Affiliations

Laparoscopic Versus Open Radical Nephrectomy for Renal Cell Carcinoma: a Systematic Review and Meta-Analysis

Gang Liu et al. Transl Oncol. 2017 Aug.

Abstract

Background: The aim of this study is to summarize and quantify the current evidence on the therapeutic efficacy of laparoscopic radical nephrectomy (LRN) compared with open radical nephrectomy (ORN) in patients with renal cell carcinoma (RCC) in a meta-analysis.

Methods: Data were collected by searching Pubmed, Embase, Web of Science, and ScienceDirect for reports published up to September 26, 2016. Studies that reported data on comparisons of therapeutic efficacy of LRN and ORN were included. The fixed-effects model was used in this meta-analysis if there was no evidence of heterogeneity; otherwise, the random-effects model was used.

Results: Thirty-seven articles were included in the meta-analysis. The meta-analysis showed that the overall mortality was significantly lower in the LRN group than that in the ORN group (odds ratio [OR] =0.77, 95% confidence interval [CI]: 0.62-0.95). However, there was no statistically significant difference in cancer-specific mortality (OR=0.77, 95% CI: 0.55-1.07), local tumor recurrence (OR=0.86, 95% CI: 0.65-1.14), and intraoperative complications (OR=1.27, 95% CI: 0.83-1.94). The risk of postoperative complications was significantly lower in the LRN group (OR=0.71, 95% CI: 0.65-0.78). In addition, LRN has been shown to offer superior perioperative results to ORN, including shorter hospital stay days, time to start oral intake, and convalescence time, and less estimated blood loss, blood transfusion rate, and anesthetic consumption.

Conclusion: LRN was associated with better surgical outcomes as assessed by overall mortality and postoperative complications compared with ORN. LRN has also been shown to offer superior perioperative results to ORN.

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Figures

Figure 1
Figure 1
Flowchart for the selection of eligible studies.
Figure 2
Figure 2
Relative risk of overall mortality comparing patients in the LRN group to those in the ORN group.
Figure 3
Figure 3
Relative risk of cancer-specific mortality comparing patients in the LRN group to those in the ORN group.
Figure 4
Figure 4
Relative risk of local recurrence comparing patients in the LRN group to those in the ORN group.
Figure 5
Figure 5
Relative risk of intraoperative complications comparing patients in the LRN group to those in the ORN group.
Figure 6
Figure 6
Relative risk of postoperative complications comparing patients in the LRN group to those in the ORN group.
Figure 7
Figure 7
Funnel plots to explore publication bias in the estimates of overall mortality (A), cancer-specific mortality (B), local recurrence (C), intraoperative complications (D), and postoperative complications (E). The vertical line is at the mean effect size.
See this image and copyright information in PMC

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