Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2017 Oct;124(10):1449-1456.
doi: 10.1016/j.ophtha.2017.04.021. Epub 2017 May 24.

24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma

C Gustavo De Moraes  1 , Donald C Hood  2 , Abinaya Thenappan  3 , Christopher A Girkin  4 , Felipe A Medeiros  5 , Robert N Weinreb  5 , Linda M Zangwill  5 , Jeffrey M Liebmann  6
Affiliations
Comparative Study

24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma

C Gustavo De Moraes et al. Ophthalmology. 2017 Oct.

Abstract

Purpose: To investigate the prevalence of visual field defects in glaucomatous eyes, glaucoma suspects, and ocular hypertensives with 24-2 and 10-2 visual fields.

Design: Prospective, cross-sectional study.

Participants: Patients with or suspected glaucoma tested with 24-2 and 10-2. Patients were classified into 3 groups on the basis of the presence of glaucomatous optic neuropathy (GON) and 24-2 visual field abnormalities: early glaucoma (GON and abnormal visual field, mean deviation >-6 decibels [dB]), glaucoma suspects (GON and normal visual field), and ocular hypertensives (normal disc, normal visual field, and intraocular pressure >22 mmHg). For the classification of visual field abnormalities, 24-2 and 10-2 tests performed on the same visit were analyzed.

Main outcome measures: Comparison of the prevalence of abnormal 24-2 versus 10-2 visual field results based on cluster criteria in each diagnostic group.

Results: A total of 775 eyes (497 patients) were evaluated. A total of 364 eyes had early glaucoma, 303 eyes were glaucoma suspects, and 108 eyes were ocular hypertensives. In the glaucoma group, 16 of the 26 eyes (61.5%) classified as normal based on cluster criteria on 24-2 tests were classified as abnormal on 10-2 visual fields. In eyes with suspected glaucoma, 79 of the 200 eyes (39.5%) classified as normal on the 24-2 test were classified as abnormal on 10-2 visual fields. In ocular hypertensive eyes, 28 of the 79 eyes (35.4%) classified as normal on the 24-2 were classified as abnormal on the 10-2. Patients of African descent were more likely to have an abnormal 10-2 result (67.3 vs. 56.8%, P = 0.009).

Conclusions: Central visual field damage seen on the 10-2 test is often missed with the 24-2 strategy in all groups. This finding has implications for the diagnosis of glaucoma and classification of severity.

Trial registration: ClinicalTrials.gov NCT00221923.

PubMed Disclaimer

Figures

Figure
Figure
The region within the blue outline on the 24-2 visual fields corresponds to the region in the central 10° tested by the 10-2 visual field test points. All fields are presented in right eye view. (A) Both superior hemifields are abnormal. (B) The superior hemifield is normal on the 24-2, but abnormal on the 10-2. (C) The superior hemifield is abnormal on the 24-2, but normal on the 10-2. Source: Traynis I, De Moraes CG, Raza AS, et al. JAMA Ophthalmology. 2014;132(3):291–297.
See this image and copyright information in PMC

Comment in

References

    1. Hood DC, Raza AS, de Moraes CG, et al. Glaucomatous damage of the macula. Prog Retin Eye Res. 2013;32:1–21. - PMC - PubMed
    1. Drance SM. The early field defects in glaucoma. Invest Ophthalmol. 1969;8:84–91. - PubMed
    1. Langerhorst CT, Carenini LL, Bakker D, De Bie-Raakman MAC. Measurements for description of very early glaucomatous field defects. In: Wall M, Heiji A, editors. Perimetry Update 1996/1997. New York, NY: Kugler Publications; 1997.
    1. Traynis I, De Moraes CG, Raza AS, et al. Prevalence and nature of early glaucomatous defects in the central 10 degrees of the visual field. JAMA Ophthalmol. 2014;132:291–297. - PMC - PubMed
    1. Park HY, Hwang BE, Shin HY, Park CK. Clinical Clues to Predict the Presence of Parafoveal Scotoma on Humphrey 10-2 Visual Field Using a Humphrey 24-2 Visual Field. Am J Ophthalmol. 2016;161:150–159. - PubMed

MeSH terms

Associated data