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Review
. 2017 Aug;471(2):235-242.
doi: 10.1007/s00428-017-2153-8. Epub 2017 May 27.

Colorectal cancer molecular profiling: from IHC to NGS in search of optimal algorithm

Larissa V Furtado  1 , Wade S Samowitz  2
Affiliations
Review

Colorectal cancer molecular profiling: from IHC to NGS in search of optimal algorithm

Larissa V Furtado et al. Virchows Arch. 2017 Aug.

Abstract

Advances in defining the mutational landscape of colorectal cancer (CRC) over the past decades have revolutionized the molecular understanding and clinical testing algorithms for this disease. Mutation testing is standard of care for the work-up of CRCs. This review focuses on the current indications and strategies for molecular testing in CRC and discusses the potential changes in CRC testing approach associated with the emerging clinical application of genomic-based technologies.

Keywords: Biomarker; Colorectal cancer; IHC; Lynch syndrome; Next-generation sequencing; Personalized medicine.

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