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Randomized Controlled Trial
. 2017 Aug;34(8):1051-1058.
doi: 10.1007/s10815-017-0949-8. Epub 2017 May 27.

Pregnancy after endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination cycles-a randomized controlled trial

Tuhina Goel  1 , Reeta Mahey  2 , Neerja Bhatla  1 , Mani Kalaivani  3 , Sangeeta Pant  1 , Alka Kriplani  1
Affiliations
Randomized Controlled Trial

Pregnancy after endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination cycles-a randomized controlled trial

Tuhina Goel et al. J Assist Reprod Genet. 2017 Aug.

Abstract

Purpose: To study the effect of endometrial scratching in infertile couples undergoing ovulation induction and intrauterine insemination (IUI) cycles.

Methods: A prospective randomized controlled trial was conducted in the Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India. One hundred forty-four women with primary/secondary infertility were recruited. Couples were either unexplained or male factor infertility. Subjects were randomized into intervention (scratching) and control group. All patients received ovulation induction with clomiphene citrate (day 2-6) 50 mg/day +75 IU HMG on days 6 and 7. In addition, endometrial scratching was done on day 8 of ovulation induction cycle in intervention group. All couples were planned for three cycles of ovulation induction and IUI over 6 months. After each failed cycle, couple was advised to try for natural conception for one cycle. Those who conceived were excluded from further analysis. Primary outcome was clinical pregnancy rate. Secondary outcome measures included conception rate, ongoing pregnancy, abortion and ectopic rate.

Results: Baseline characteristics were comparable in both groups. Clinical pregnancy rate was significantly higher in intervention group (31.9%; 23/72) as compared to control group (16.7%; 12/72) (p value 0.030). On per cycle analysis, first IUI cycle had significantly high pregnancy rate (18.1%; 13/72) as compared to control group (5.6%; 4/72). Three patients in intervention group and one in control group conceived in wash out cycle. Ongoing pregnancy rate was significantly higher in scratching group (30.0%; 21/70) as compared to control group (15.7%; 11/70) (p value0.044).

Conclusions: Endometrial scratching can be used as a low cost-effective tool to improve clinical pregnancy and ongoing pregnancy rate in IUI cycles. Further large number studies are required to document its role in improving live birth rate.

Trial registration number: CTRI/2015/12/006419.

Keywords: Endometrial receptivity; Endometrial scratching; Implantation; Infertility.

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Conflict of interest statement

Conflict of interest

The authors declare that they have no conflict of interest.

Animal studies

No animals were used.

Informed consent

Informed consent was taken from all the patients participating in the study.

Figures

Fig. 1
Fig. 1
Consort diagramme
Fig. 2
Fig. 2
Forest plot showing the primary and secondary outcomes in intervention and control group
See this image and copyright information in PMC

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