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Review
. 2017 Jul 30;23(3):341-348.
doi: 10.5056/jnm16203.

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Adam Fabisiak  1 , Jakub Włodarczyk  1 , Natalia Fabisiak  1 , Martin Storr  2   3 , Jakub Fichna  1
Affiliations
Review

Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal

Adam Fabisiak et al. J Neurogastroenterol Motil. .

Abstract

Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed.

Keywords: Ebastine; Irritable bowel syndrome; Mast cells; Receptors, histamine.

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Conflict of interest statement

Conflicts of interest: None.

Figures

Figure
Figure
Localization of histamine receptors in the intestinal wall.
See this image and copyright information in PMC

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