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Comment
. 2017 Jun 12;31(6):731-733.
doi: 10.1016/j.ccell.2017.05.004. Epub 2017 May 25.

Ibrutinib in PCNSL: The Curious Cases of Clinical Responses and Aspergillosis

Christian Grommes  1 , Anas Younes  2
Affiliations
Comment

Ibrutinib in PCNSL: The Curious Cases of Clinical Responses and Aspergillosis

Christian Grommes et al. Cancer Cell. .

Abstract

In this issue of Cancer Cell, Lionakis et al. demonstrate that the combination of temozolomide, etoposide, doxorubicin, dexamethasone, rituximab, and the Bruton tyrosine kinase (BTK) inhibitor ibrutinib induced frequent responses in patients with primary central nervous system lymphoma but was associated with significant toxicity, including pulmonary and cerebral aspergillosis infections.

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Figures

Figure 1
Figure 1. Therapeutic Targeting of BTK in PCNSL
(A) Activity of single-agent ibrutinib in PCNSL. (B) Ibrutinib inhibition of BTK in tumor cells induces favorable clinical responses, while inhibition of BTK in monocytes may lead to an increased incidence of invasive aspergillosis.
See this image and copyright information in PMC

Comment on

  • Inhibition of B Cell Receptor Signaling by Ibrutinib in Primary CNS Lymphoma.
    Lionakis MS, Dunleavy K, Roschewski M, Widemann BC, Butman JA, Schmitz R, Yang Y, Cole DE, Melani C, Higham CS, Desai JV, Ceribelli M, Chen L, Thomas CJ, Little RF, Gea-Banacloche J, Bhaumik S, Stetler-Stevenson M, Pittaluga S, Jaffe ES, Heiss J, Lucas N, Steinberg SM, Staudt LM, Wilson WH. Lionakis MS, et al. Cancer Cell. 2017 Jun 12;31(6):833-843.e5. doi: 10.1016/j.ccell.2017.04.012. Epub 2017 May 25. Cancer Cell. 2017. PMID: 28552327 Free PMC article.

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