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Review
. 2017 May 12:9:331-335.
doi: 10.2147/BCTT.S111394. eCollection 2017.

Current perspectives on CHEK2 mutations in breast cancer

Panagiotis Apostolou  1 , Ioannis Papasotiriou  1
Affiliations
Review

Current perspectives on CHEK2 mutations in breast cancer

Panagiotis Apostolou et al. Breast Cancer (Dove Med Press). .

Abstract

Checkpoint kinase 2 (CHEK2) is a serine/threonine kinase which is activated upon DNA damage and is implicated in pathways that govern DNA repair, cell cycle arrest or apoptosis in response to the initial damage. Loss of kinase function has been correlated with different types of cancer, mainly breast cancer. CHEK2 functionality is affected by different missense or deleterious mutations. CHEK2*1100delC and I157T are most studied in populations all over the world. Although these variants have been identified in patients with breast cancer, their frequency raises doubts about their importance as risk factors. The present article reviews the recent advances in research on CHEK2 mutations, focusing on breast cancer, based on the latest experimental data.

Keywords: CHEK2; breast cancer.

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Conflict of interest statement

Disclosure The authors report no conflicts of interests in this work.

Figures

Figure 1
Figure 1
CHEK2 pathway. CHEK2 is activated upon DNA damage. It is phosphorylated followed by homodimerization. In this form, it interacts with other genes affecting specific cellular activities in response to the initial damage. Abbreviations: CHEK2, checkpoint kinase 2; P, phosphorylated protein.
See this image and copyright information in PMC

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