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. 2017 Apr 1;8(4):2588-2591.
doi: 10.1039/c6sc05581h. Epub 2017 Jan 10.

Cobalt-catalysed C-H carbonylative cyclisation of aliphatic amides

Patrick Williamson  1 , Alicia Galván  1 , Matthew J Gaunt  1
Affiliations

Cobalt-catalysed C-H carbonylative cyclisation of aliphatic amides

Patrick Williamson et al. Chem Sci. .

Abstract

A cobalt-catalysed C-H carbonylation of aliphatic carboxamide derivatives is described, employing commercially available Co(ii)-salts in the presence of a silver oxidant. This operationally simple process utilises an atmospheric pressure of CO and generates a range of substituted succinimide products bearing diverse functional groups that can be successfully accessed via this methodology.

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Figures

Scheme 1
Scheme 1. A Co-catalysed C–H carbonylation strategy.
Scheme 2
Scheme 2. Investigation of substrate structure and lead reaction.
Scheme 3
Scheme 3. Product derivatisations.
See this image and copyright information in PMC

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